INNO-LIA™ HTLV I/II Score
INNO-LIA™ HTLV I/II Score is a line immunoassay for confirmation and discrimination of human T-cell lymphotrophic virus type I (HTLV I) and type II (HTLV II) infections.
Article number: 80541 (20T - CE)
Finally, a clear answer in HTLV confirmation
Features & Benefits
- Confirmation and discrimination in one step
-
Few indeterminate results
-
Optimal specificity in screened-negative blood donors: 99,7% (304/305)
-
Optimal sensitivity for HTLV I (100%; 218/218) and HTLV II (100%; 112/112)
-
Short and overnight procedures
-
Color-coded reagents
-
Ready-to-use reagents
-
-
Strip design
INNO-LIA™ HTLV I/II Score
INNO-LIA™ HTLV I/II Score is a line immunoassay to confirm the presence of antibodies to human T-cell lymphotropic virus type I (HTLV I) and type II (HTLV II) in human serum or plasma. The assay also differentiates between HTLV I and HTLV II infections.
The assay uses well-defined antigens derived from HTLV I and HTLV II immunodominant proteins. The antigens are either recombinant proteins or synthetic peptides that are purified and fixed on a nylon membrane. The antigenicity exhibited by these proteins and peptides is either common to HTLV I and HTLV II antibodies or type-specific to one of the two viruses allowing confirmation and discrimination in a single assay. Two gag bands (p19 I/II, p24 I/II) and two env (gp46 I/II, gp21 I/II) bands are applied as non-type-specific antigens, used to confirm the presence of antibodies against HTLV I/II. The type-specific antigens (gag p19-I, env gp46-I) specific for HTLV I and (env gp46-II) specific for HTLV II, enable differentiation of HTLV I and HTLV II infections. In addition, the strip includes one streptavidin control line, two control lines (human IgG), and one strong positive control line (anti-human IgG), which also serves as a sample addition control line.
Click INNO-LIA™ HTLV I/II Score to view the commercial leaflet.
Publications
Background
Human T-cell lymphotropic viruses type I and II (HTLV I and HTLV II) are related exogenous human retroviruses. HTLV I was first isolated in 1980 from a patient with cutaneous T-cell lymphoma and, in 1982, HTLV II was identified in a patient with hairy cell leukaemia.
HTLV I has mainly been etiologically linked with a lymphoproliferative disease known as adult T-cell leukaemia’ (AT), a chronic myelopathy known as ‘tropical spastic paraparesis’ (TSP), and also with other inflammatory conditions. HTLV II infections have not so far been associated with any type of leukaemia or other disease. Most HTLV II-infected individuals remain completely asymptomatic. The virus is transmitted from mother to child, by blood transfusion, and via sexual contact.
HTLV is endemic in Central and West Africa, the Caribbean, and parts of South America, Japan, and Melanesia/Australia. In Europe and America, HTLV is frequently detected in intravenous drug users.
Customer support
For all inquiries regarding Innogenetics products and instrumentation, we offer the services of our customer support team. This team of technical experts is committed to dealing with
-
General inquiries
-
Technical assistance
-
Complaint resolution
The customer support team is designed to be your principle point of contact. They will ensure that the appropriate person handles all product-related inquiries. For this service please contact us via e-mail, call us (+32-9 329 16 11), or fax (+32-9 329 17 75).