Diagnostics

Neurodegeneration

INNOTEST^® hTau Ag

INNOTEST^® hTau Ag is an ELISA microplate assay for the quantitative determination of human tau, antigen in cerebrospinal fluid (CSF).

Combined use of CSF-tau and CSF-Aß1-42 markers allows differentiation between Alzheimer’s disease (AD) and normal aging or other neurologic disorders such as depression (1-5).

Article number: 80323 (96T)

The CE-marked kit allows easy, reliable, and specific quantification of CSF-tau. The combined use of CSF-tau and CSF-Aß1-42 markers allows differentiation between AD and normal aging or other neurologic disorders such as depression.

Features & Benefits

• User-friendly enzyme immunoassay
  
  
• Minimum number of handling steps
  
  
• Small sample volume: 25 µL CSF. Duplicate testing is strongly recommended and requires
  2 x 25 µL CSF
  
  
• Reproducible results within the standards range
  
  
• Lowest detection limit: 60 pg/mL
  Standards range: 75 to 1200 pg/mL

Publications

• Are elevated CSF tau levels in Alzheimer patients related to clinical parameters?
• CSF-phospho-tau (181P) as a promising marker for discriminating Alzheimer’s disease from dementia with Lewy bodies.
• CSF tau is related to apolipoprotein E genotype in early Alzheimer’s disease.
• Phosphorylated tau in cerebrospinal fluid as marker for Creutzfeldt-Jacob disease.
• Total tau and phosphorylated tau 181 levels in the cerebrospinal fluid of patients with frontotemporal dementia due to P301L and G272V tau mutations.
• CSF markers for incipient Alzheimer's disease.
• Levels of tau protein in cerebrospinal fluid are correlated with neuronal loss in Alzheimer’s disease.
• Improved discrimination of AD patients using ß-amyloid(1-42) and tau levels in CSF.
• CSF markers for the diagnosis of Alzheimer’s disease.
• Effects of cholinesterase inhibitors on Alzheimer’s disease biomarkers.
• Highly increased CSF tau protein and decreased ß-amyloid (1-42) in sporadic CJD: a discrimination from Alzheimer’s disease?
• Value of CSF beta-amyloid(1-42) and tau as predictors of Alzheimer's disease in patients with mild cognitive impairment.
• Basic and Clinical Studies on the Measurement of Tau Protein in Cerebrospinal Fluid as a Biological Marker for Alzheimer’s Disease and Related Disorders: Multi center Study in Japan.
• Cerebrospinal fluid tau and Aß42 as predictors of development of Alzheimer’s disease in patients with mild cognitive impairment.

Background

1. Hulstaert F, Blennow K, Ivanoiu A, Schoonderwaldt HC, Riemenschneider M, De Deyn PP, et al. Improved discrimination of AD patients using ß-amyloid1-42 and tau levels in CSF. Neurology 1999;52:1555-1562.
2. Galasko D, Chang L, Motter R, Clark CM, Kaye J, Knopman D, et al. High cerebrospinal fluid tau and low amyloid ß42 levels in the clinical diagnosis of Alzheimer’s disease and relation to apolipoprotein E genotype. Arch Neurol 1998;55:937-945.
3. Shoji M, Kanai M, Matsubara E, Ikeda M, Harigaya Y, Okamoto K, et al. Taps to Alzheimer’s patients: a continuous Japanese study of cerebrospinal fluid markers. Ann Neurol 2000;48:402.
4. Andreasen N, Minthon L, Davidsson P, Vanmechelen E, Vanderstichele H, Winblad B, et al. Evaluation of CSF-tau and CSF- Aß42 as diagnostic markers for Alzheimer’s disease in clinical practice. Arch Neurol 2001;58:373-379.
5. Sunderland T, Linker G, Mirza N, Putnam KT, Friedman DL, Kimmel LH, et al. Decreased b-amyloid1-42 and Increased Tau Levels in Cerebrospinal Fluid of Patients With Alzheimer disease. Journal of the American Medical Association 2003;289:2094-2103.

Additional useful information about Alzheimer’s disease can be found on the following websites:
The Alzheimer forum site:
http://www.alzforum.org/new/detail.asp?id=875
http://www.alzforum.org/new/detail.asp?id=804
http://www.alzforum.org/new/detail.asp?id=709

Customer support

For all inquiries regarding Innogenetics products and instrumentation, we offer the services of our customer support team. This team of technical experts is committed to dealing with

• General inquiries
• Technical assistance
• Complaint resolution

The customer support team is designed to be your principle point of contact. They will ensure that the appropriate person handles all product-related inquiries. For this service please contact us via e-mail, call us (+32-9 329 16 11), or fax (+32-9 329 17 75).