INNOTEST® hPLAP
INNOTEST® hPLAP is an enzyme immunoassay based on a unique monoclonal antibody for the quantitative determination of human placental alkaline phosphatase (hPLAP) in serum and heparinized plasma.
Article number: 80326 (96T - CE)
hPLAP is a marker for diagnosis and monitoring of seminomas
Features & Benefits
- Serum or heparinized plasma
- Ready-to-use standards
- No sample pre-dilution
- Non-isotopic assay
- 8-well strips
Background
It has long been known that hPLAP is present in the serum of pregnant women, from the second trimester onwards. The origin of this isoenzyme is the placental trophoblast.
The discovery of hPLAP by the group of W.H. Fischman in serum and tumor tissue of a male cancer patient heralded the beginning of "oncodevelopmental biology". Since then, extensive research has indicated that in a number of types of cancer hPLAP is present in the patient's serum.
The application of monoclonal antibodies specific for hPLAP enables measurement of this enzyme without interference from other alkaline phosphatase (AP) isoenzymes.
The hPLAP assay is an additional tool in the confirmation of diagnosis and in the monitoring of cancer patients, particularly those with seminoma, testicular, or ovarian cancer. Persistently increasing hPLAP levels may well be associated with progressive malignant disease or poor response to therapy, whereas declining hPLAP levels may be indicative of good response to treatment or of recovery.
Studies indicate that smoking habits of subjects should be taken into account when evaluating serum hPLAPlevels.
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